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Latest innovation in shearing -
Bioruptor Pico

The Bioruptor® Pico is a breakthrough all-in-one shearing system that can simultaneously sonicate 6-16 samples.* The Pico utilizes an advanced water bath sonication system that is optimized for gentle, yet powerful homogeneous shearing micro-volumes of 5 μl to larger samples of up to 2 ml. The unique cooling system includes a water cooler and single cycle valve to provide high precision temperature control that result in highest quality samples.

Ideal for:

  • DNA shearing for Next-Generation-Sequencing (5 - 100 µl)
  • Chromatin shearing (10 µl - 2 ml)
  • RNA shearing (200 bp – 1 kb)
  • Protein extraction from tissues and cells
  • FFPE DNA extraction

Key application notes and publications


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Technical specifications

Shearing Chromatin shearing 200 bp – 1 kb
DNA shearing 150 bp – 1 kb
RNA shearing 200 bp – 1 kb
Throughput 16 samples (0.2 ml tube holder)
12 samples (0.1 and 0.65 ml tube holders)
6 samples (1.5 and 15 ml tube holders)
Volumes 5 - 50 µl (0.1 ml tubes)
20 - 100 µl (0.2 ml tubes)
100 µl (0.65 ml tubes)
100 - 300 µl (1.5 ml tubes)
300 µl - 2 ml (15 ml tubes)
Unit dimensions 35.5 [W] x 24.5 [D] x 28 [H] cm
14 [W] x 9.6 [D] x 11 [H] in
Weight 7.9 kg (17.4 lb)

Accessories, consumables and QC kits

Catalogue number Description
DIAG-B01200041 Bioruptor Pico tube holder 0.1 ml and tube adaptors
DIAG-B01200044 Bioruptor Pico tube holder 0.2 ml
DIAG-B01200043 Bioruptor tube holder 0.5/0.65 ml
DIAG-B01200040 Bioruptor Pico tube holder 1.5 ml
DIAG-C30010015 Bioruptor Pico 0.1 ml tubes – 120 pc
DIAG-C30010020 Bioruptor Pico 0.2 ml tubes – 1000 pc
DIAG-C30010011 Bioruptor Pico 0.65 ml tube – 500 pc
DIAG-C30010016 Bioruptor Pico 1.5 ml tubes with caps – 300 pc
DIAG-C30010017 Bioruptor Pico 15 ml tubes – 50 pc
DIAG-C01020031 Bioruptor Pico 15 ml tubes and sonication beads – 50 pc
DIAG-C30010015 Bioruptor Pico 0.1 ml tubes – 120 pc
DIAG-C40010002 Bioruptor Pico DNA QC Kit – 1 pc

Other shearing instruments

Diagenode One

Diagenode One
Desktop sonication device

Compact bench top device for simple NGS library preparation

Bioruptor Plus

Bioruptor Plus
Advanced water bath sonicator

Cell and tissue sample preparation
Sample preparation for mass spectrometry analysis

Megaruptor 2

Megaruptor® 2
Hydrodynamic shearing instrument

Superior solution for long read sequencing library preparation

Please refer to this chart to compare shearing instruments for NGS.

* LGC’s distribution agreement includes EMEA, South America and Canada for all market sectors and the United States for the agricultural biotechnology sector.