Measurements for Pharma

• Choice of multiple ICP-MS platforms, separation techniques and sample preparation; more than 20 measurement experts
• Trace level analysis in complex matrices (including clinical)

-Elements/metals: screening or quantitative under ISO17025 accreditation

-Species: Inorganic arsenic, Cr(III) and Cr(VI) and Selenomethionine (ISO/IEC 17025 accredited)

-Nanoparticles: SiO2, ZnO, Ag, TiO2 and Au)

-Metalloprotein

• • • Selenium proteins, including Selenoprotein P,Glutathione peroxidase 3 and Se-Albumin
    • Copper-proteins, including Cu-Albumin and Cu-Ceruloplasmin
    • Adducts of metallodrugs with plasma proteins and/or DNA
• External validation and value assignment
• Imaging (biological tissue)
• Isotope ratio

• Choice of multiple MS platforms, separation techniques and sample preparation; more than 20 measurement experts
• Proof of concept and early stage development

-Method development for multiple analytes (small and large molecules), complex matrices (including clinical) and ultra trace level (pre-GMP)

• • • Better diagnostics (for biomarker selection and quantification) / ideal sub-contractor for MRC grants
    • Better therapeutics (establish QA measures, better formulation/manufacturing/stability)
• External validation and provision of traceable measurements

-IVD Regulation (2017) / metrological traceability of calibrant

-Standard value assignment of QC materials (if not available commercially)

• • • AAs, peptides and clinical such as creatinine, tacrolimus and digoxin (recognised international experts)
    • Serum, blood, plasma and solutions at ultra-trace levels (low ppb)
• Structure elucidation of impurities and drugs metabolites
• Peptide quant
• Epitope mapping