Pharma - What, benefits and other services

 

  • Structure elucidation and confirmation (API and impurities)

  • Fast purity determination by QNMR (alternative to mass balance approach)

  • Ability to recover precious sample (only 10 mg required)

  • Troubleshooting

    • Complementary to that provided by analytical techniques e.g. LC-MS and GC-MS (able to distinguish structural isomers)
    • Fast screen for main components of the sample with ability to identify and quantify impurities down to 0.1 %
    • Fast analytical standard comparison – batch to batch variation for quality control purposes
  • Stability

    • Capability to study stability (real-time) of actives in solution varying factors such as temperature, pH and buffer
    • Understand quickly changes in structure (isomer, protonation, tautomer, etc..) and formation of impurities or by-products
  • Oligonucleotide and large molecules

    • Fingerprinting in addition to other analytical data
      • Is the NMR data (region and functional groups) consistent with proposed structure?
    • Fast batch to batch verification
    • Can provide evidence of secondary structure