Material science testing

Capabilities

LGC is highly experienced in the application of a broad range of material characterisation techniques and packages and has the knowledge to support your product development from discovery to product registration and beyond. Our experience includes working with APIs, excipients, process impurities, degradation products and formulated products.

Techniques:

Physical Properties Testing

  • Optical Microscopy
  • Scanning Electron Microscopy (SEM) with Energy Dispersive X-ray (EDX)
  • Particle sizing (Malvern and Sympatec: Wet and Dry methods)
  • Particle shape by image analysis (QICPIC)
  • Specific Surface Area by gas adsorption
  • Inverse Gas Chromatography – Surface Energy Analysis (iGC-SEM)
  • Dynamic vapour sorption
  • Density (bulk and tapped)
  • Sieve testing
  • Porosity
  • Dissolution


Solid Form Characterisation

  • Powder X-ray diffraction
  • Differential scanning calorimetry
  • Thermogravimetric analysis
  • FT-IR
  • Thermo-microscopy
  • Assessment of amorphous / crystalline form
  • Determination of hydrates, solvates and co-crystals
  • Crystal structure solution and solid form risk assessment


LGC has extensive experience in working with many product-delivery platforms and formulation types, and supports routine measurements, advanced characterisation, and bespoke method development and validation for all stages of your product development and manufacturing pipeline.


Applications

  • Bulk powder handling and processing
  • Solid form issues such as polymorphism, solvates, salts and co-crystals
  • Chemical and physical stability
  • Dissolution, crystallisation and segregation
  • Compatibility between ingredients and packaging
  • Polymer deformulation and glass delamination
  • Pilot plant and commercial scale manufacturing
  • Supplier change and raw materials evaluation studies
  • Foreign particulates and contaminant identification
  • Root cause analysis of API and drug product failures
  • IP, patent litigation and counterfeits testing
  • Due diligence activities for in-licensed compounds
  • Analytical method transfer exercises