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University of Nottingham - app note

Our new application note from the University of Nottingham compares the effectiveness of two genotyping technologies, TaqMan® and KASP™, for successful design of custom genotyping assays for a novel rare deleterious missense coding variant linked to Alzheimer’s disease. The variant was identified from a next-generation sequencing study analysing gene loci previously linked with Alzheimer’s disease by GWAS.
 
At LGC we have optimised our KASP assay design algorithms and validation processes to ensure that we can design effective assays for all sorts of genetic variation, including rare variants. We have worked at improving our chemistry for over a decade and we are proud to see that leading academic centres find that our KASP technology can outperform other genotyping methods such as TaqMan when it comes to designing challenging assays such as the one in this example.
 

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University of Nottingham – Human Genetics group 317KB

Application note: Comparison of custom designed KASP and TaqMan genotyping assays for a rare genetic variant identified through resequencing GWAS loci