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Reference materials and measurements

LGC’s role as National Measurement Institute                                                           

LGC has been designated the role of National Measurement Institute (NMI) for chemical and bio-measurements in the UK. A key activity within this role is to support the measurement community through the provision of high-order, primary reference materials. These materials are certified under ISO Guide 34 accreditation, using primary methods of analysis that are validated by comparison with other worldwide NMIs, such as NIST in the USA. These materials consist of pure organic compounds to be used for calibration as well as a wide range of complex matrix materials for validation or development of analytical techniques across numerous sectors. Examples of these matrix CRMs are alcohol standards for the calibration of breathe-analyzers, trace contaminants and nutrients in food and drugs or drug metabolites in biological samples.

These materials are independently peer-reviewed by our colleagues in the ERM® consortium and thus the users of these materials can be absolutely sure of the metrological traceability and reliability.

LGC collaborates with National Institute of Standards and Technology (NIST)

Designed for use in the certification of aqueous based calibration solutions of single elements, LGC has collaborated with the National Institute of Standards and Technology (NIST) in the USA to develop and implement a protocol using high performance ICP-AES. This technique provides direct traceability of both the analyte concentration and the associated uncertainty value of a CRM to the SI unit. LGC also produces a range of custom-made multi-element aqueous solution standards.

Oil-based reference materials    
                                                                                          

LGC has developed unique methods to synthesize metallo-organic materials that offer the necessary purity and stability required to produce a complete range of single and multi-element CRMs in organic matrices, certified to ISO Guide 34.

LGC is on the forefront of manufacturing testing standards for biofuel materials.  ASTM methods D7651, D5453 and EN14214 specify requirements and testing methods for B100 biodiesel and LGC offers standards for a range of metals that meet specifications for this testing, both in single element and multi-element blends.

Solid alloyed-metal CRMs   

LGC provides a full line of solid alloyed-metal CRMs (Certified Reference Materials) and RMs (Reference Materials) for calibration and standardization of both optical emission and XRF spectrometers.  CRMs are rigorously certified through the Inter-Laboratory Analysis Program, where member laboratories provide analytical results from multiple analytical disciplines.  This approach results in publishing the most reliable certificate values for the broadest range of elements possible.  CRM alloy groups include CLATS (Carbon Low-Alloy Tool Steel), Stainless and High-Temperature Steels, Nickel Alloys, Cobalt Alloys, Copper, Brass and Bronze Alloy and Titanium and Zirconium Alloys.  LGC also provides PT programs for a wide range of metal matrices.

Synthesis & characterisation of calibrant compounds for pharmaceutical impurity, toxicology and drug analyses

 LGC’s capabilities include in-house synthesis (pharmaceutical impurities, metabolites, labelled compounds etc.) and characterization/testing in our ISO 17025 accredited testing laboratory of over 3000 materials.  Many of the substances are produced and accredited according to ISO Guide 34 requirements. These include reference materials for organic neat compounds and for reference materials in the form of solutions, and serve the pharmaceutical, forensics, clinical and life sciences market sectors.

Pesticides, food and other organic reference materials

LGC is the leading manufacturer of pesticide residue and other organic contaminant standards for the food, environmental and healthcare industries, with over 8000 products that are produced under ISO/IEC 17025 and ISO Guide 34 quality systems at our dedicated facilities in Germany. Many very specialized materials are continually being developed in response to new emerging contaminants of concern and advancing analytical capabilities.